Celox™ is made using Chitosan, a natural polymer extracted from the shells of shrimp and crabs. Chitosan is a polysaccharide (long chain of sugars) and has some very interesting properties when treated the right way. The Chitosan in Celox™ has been reacted to improve many of its properties. The result is a very effective product.
We use a very special grade of Chitosan to make Celox™. It is a highly purified derivative of shrimp shells caught in the pure waters of the Arctic Ocean.
Chitosan has a known metabolic pathway and is digested by lysozyme; a human enzyme, which is present, in tears, saliva, and mucus. That means any Chitosan left in the body gets broken down to give glucosamine (an amino-sugar which is already present in the body that helps lubricate joints). Reference (Int. J. Biol. Macromol., 1992, Vol 14 August).
Chitosan is used widely and is in such products as medical bandages, diet aids and some cosmetics. It is an approved food ingredient.
The Chitosan used in Celox™ has been affirmed to the US FDA as GRAS under 21 CFR ξ170.30. This terminology is used for materials which have been thoroughly assessed and reviewed by panel of experts and are deemed to be generally regarded as safe (GRAS). As part of this work it has been tested on 221 human subjects with suspected hypersensitivity. None of the subjects showed any skin reaction to the Chitosan. 11 of the subjects gave a positive reaction in a standard fish/shrimp prick test but did not react to this highly purified Chitosan.